A Population Genetics Model of Marker-Assisted Selection

A population genetics model of marker-assisted selection.

A deterministic two-loci model was developed to predict genetic response to marker-assisted selection (MAS) in one generation and in multiple generations. Formulas were derived to relate linkage disequilibrium in a population to the proportion of additive genetic variance used by MAS, and in turn to an extra improvement in genetic response over phenotypic selection. Predictions of the response ...

Breeding and Genetics: Molecular Genetics, QTL Detection and Marker Assisted Selection

Putative quantitative trait loci (QTL) affecting conformation traits in Holsteins have been detected using genotypic data generated by two research groups. Each research group conducted an independent genome scan in a select group of Holstein grandsire families. Six families were used by both groups and genotyped for 367 microsatellite markers in order to identify QTL affecting milk production ...

A mutation and selection model in population genetics

We construct a new continuous time selection-mutation-recombination model for population dynamics, which describes the development of the distribution of the different gametes in the population. We show that cyclic mutation rates can result in stable and unstable limit cycles due to Hopf -bifurcation. In addition, we give a qualitative characterization of the whole dynamics in the simplex, whic...

Genomic selection: marker assisted selection on a genome wide scale.

Genomic selection (GS) has become a very intense field of research during recent years. GS may be defined as the simultaneous selection for many (tens or hundreds of thousands of) markers, which cover the entire genome in a dense manner so that all genes are expected to be in linkage disequilibrium with at least some of the markers. In a sense, GS is marker assisted selection on a genome wide s...

Comparing predictive abilities of phenotypic and marker-assisted selection methods in a biparental lettuce population